| Potassium phthalimide： An efficient and green organocatalyst for the synthesis of 4-aryl-7-（arylmethylene）-3,4,6,7-tetrahydro-1H- cyclopenta[d]pyrimidin-2（5H）-ones]thiones under solvent-free conditions |
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| 作者姓名： | Hamzeh Kiyani Maryam Ghiasi |
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| 作者单位： | School of Chemistry, Damghan University, Damghan 36715-365, lran |
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| 基金项目： | The authors are thankful to Damghan University Research Council for partial support of this work. |
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| 摘 要： | An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea/thiourea is reported. The present methodology is a green approach to access 4-aryl-7-（aryImethylene）-3,4,6,7-tetrahydro-1H-cyclopentad]pyrimidin-2（5H）-ones/thiones. It offers several merits such as simple operational procedures, no use of hazardous organic solvents, and cheap and environmentally friendly solid basic catalyst.
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| 关 键 词： | 邻苯二甲酰亚胺 环戊二烯 有效合成 有机溶剂 有机小分子 芳基 嘧啶 四氢 |
| 收稿时间： | 2013-07-11 |
| 修稿时间： | 2013-11-06 |
Potassium phthalimide: An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3, 4, 6, 7-tetrahydro-1Hcyclopenta[d]pyrimidin-2(5H)-ones/thiones under solvent-free conditions |
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| Hamzeh Kiyani,Maryam Ghiasi.Potassium phthalimide: An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3, 4, 6, 7-tetrahydro-1Hcyclopenta[d]pyrimidin-2(5H)-ones/thiones under solvent-free conditions[J].Chinese Chemical Letters,2014,25(2):313-316. |
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| Authors: | Hamzeh Kiyani Maryam Ghiasi |
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| Institution: | School of Chemistry, Damghan University, Damghan 36715-365, Iran |
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| Abstract: | An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea/thiourea is reported. The present methodology is a green approach to access 4-aryl-7-(arylmethylene)-3,4,6,7-tetrahydro-1H-cyclopentad]pyrimidin-2(5H)-ones/thiones. It offers several merits such as simple operational procedures, no use of hazardous organic solvents, and cheap and environmentally friendly solid basic catalyst. |
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| Keywords: | Organocatalyst Potassium phthalimide Biginelli reaction Pyrimidinone Solvent-free |
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