| Synthesis of cyclopentenyl and cyclohexenyl ketones via [3 + 2] and [4 + 2] annulations of 1,2-allenic ketones简 |
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| 作者姓名： | Liang-Yan Cui Sheng-Hai Guo Bin Li Xin-Ying Zhang Xue-Sen Fan |
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| 作者单位： | School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory forEnvironmental Pollution Control, Henan Normal University, Xinxiang 453007, China |
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| 基金项目： | We are grateful to the National Natural Science Foundation of China (Nos. 21172057, 21272058), and the Research Fund for the Doctoral Program of Higher Education (No. 20114104110005) for financial support. |
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| 摘 要： | In this paper, an efficient synthesis of cyclopentenyl ketones and cyclohexenyl ketones through tertiary phosphine catalyzed 3 ＋ 2] and 4 ＋ 2] annulations of 1,2-allenic ketones with activated alkenes has been developed. Compared with published synthetic methods on cyclopentenyl ketones and cyclohexenyl ketones, the protocols developed in this paper have the advantages such as readily available starting materials, mild reaction conditions and high efficiency.
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| 关 键 词： | 合成方法 环己酮 丙二烯 酮类 烯基 反应条件 环戊酮 叔膦 |
| 收稿时间： | 2013-06-18 |
| 修稿时间： | 2013-09-17 |
Synthesis of cyclopentenyl and cyclohexenyl ketones via [3 + 2] and [4 + 2] annulations of 1,2-allenic ketones |
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| Liang-Yan Cui,Sheng-Hai Guo,Bin Li,Xin-Ying Zhang,Xue-Sen Fan.Synthesis of cyclopentenyl and cyclohexenyl ketones via [3 + 2] and [4 + 2] annulations of 1,2-allenic ketones[J].Chinese Chemical Letters,2014,25(1):55-57. |
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| Authors: | Liang-Yan Cui Sheng-Hai Guo Bin Li Xin-Ying Zhang Xue-Sen Fan |
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| Institution: | School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China |
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| Abstract: | In this paper, an efficient synthesis of cyclopentenyl ketones and cyclohexenyl ketones through tertiary phosphine catalyzed 3 + 2] and 4 + 2] annulations of 1,2-allenic ketones with activated alkenes has been developed. Compared with published synthetic methods on cyclopentenyl ketones and cyclohexenyl ketones, the protocols developed in this paper have the advantages such as readily available starting materials, mild reaction conditions and high efficiency. |
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| Keywords: | Cyclopentenyl ketone Cyclohexenyl ketone 1 2-Allenic ketone Phosphine-catalyzed annulation |
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