Decarbonylative radical cyclization of alpha-amino selenoesters upon electrophilic alkenes. A general method for the 6-azabicyclo[3.2.1]octane synthesis |
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| Authors: | Quirante Josefina Vila Xavier Escolano Carmen Bonjoch Josep |
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| Institution: | Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. |
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| Abstract: | alpha-Amino selenoester-tethered electronically poor alkenes on treatment with tributyltin hydride or TTMSS undergo intramolecular radical cyclization to provide 6-azabicyclo3.2.1]octanes through 1-aminomethyl radical intermediates. |
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