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A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets |
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| Authors: | Ryan A Hemming Megan Bell Liam J Duffy Jonathan Bristow John D Wallis Steven M Allin Philip C Bulman Page |
| Institution: | 1. Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK;2. School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK |
| Abstract: | A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%. |
| Keywords: | Isoindolinone Stereoselective synthesis |
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