On the solvability of a boundary-value problem for an elliptic equation

Consider a boundary-value problem for a second-order linear elliptic equation in a bounded domain. The coefficient of the required function is nonpositive everywhere in the domain, except for a small neighborhood of an interior point. The following question arises: Under what constraints on this coefficient in the given small domain do the statements on the existence and uniqueness of the solution of the first boundary-value problem remain valid?