Antibody-combining sites |
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| Authors: | David M. Webster Jan Pedersen David Staunton Alison Jones Anthony R. Rees |
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| Affiliation: | (1) Department of Biochemistry, University of Bath, BA2 7AY Claverton Down, Bath, UK |
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| Abstract: | The antibody repertoire is very large with at least 109 different antibody specificities, yet there are currently only 800 variable-region sequences known and < 23 Fab structures deposited with the Brookhaven Protein Data Bank. To engineer the antibody-combining site rationally, we need to define the rules that govern antibody structure. To understand the process of antibody-antigen recognition, we need not only to predict complementary determining regions accurately, but to simulate accurately the interaction of antibody with antigen. We have made progress in the modeling of antibody-combining sites and in the simulation of antibody complex formation. The combination of these approaches will allow us to extend the natural limits of antibody-combining sites in a more rational manner. |
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| Keywords: | Antibody antigenic epitope antibody-combining site complementarity determining region molecular docking peptide mimetics metal binding sites |
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