Electrochemical behavior of valsartan and its determination in capsules |
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Authors: | Yan Jinlong Wang Wei Chen Liang Chen Song |
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Affiliation: | School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, China. yjlyt4788@yahoo.com.cn |
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Abstract: | Electrochemical behavior of valsartan has been carried out in Britton-Robinson (B-R) buffer solution at pH 7.0 at the mercury film electrode (MFE) by cyclic, linear sweep, differential-pulse and square-wave voltammetry. The property of valsartan adsorption at the MFE using accumulation potential of +0.10 V was observed. The effects of experimental parameters on electrochemical process at the MFE were discussed. Differential-pulse adsorptive stripping and square-wave adsorptive stripping voltammetry for the valsartan determination were proposed, linearity was found in the range of 6.0 x 10(-8) to 4.0 x 10(-6)mol/L. The detection limits were 2.93 x 10(-9) and 3.27 x 10(-9)mol/L, respectively. The proposed methods were also applied to the commercial valsartan with good recoveries. |
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Keywords: | Valsartan Stripping voltammetry Differential-pulse Square-wave Electroanalysis |
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