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| 4-甲基-5-(2-羟乙基)噻唑的合成新工艺 | |
| 引用本文： | 张小林,李海峰,欧阳红霞,朱礼良. 4-甲基-5-(2-羟乙基)噻唑的合成新工艺[J]. 南昌大学学报(理科版), 2011, 35(3) |
| 作者姓名： | 张小林 李海峰 欧阳红霞 朱礼良 |
| 作者单位： | 1. 南昌大学 化学系,江西南昌 330031;南昌大学 抚州医学分院,江西抚州 344000 2. 南昌大学 化学系,江西南昌,330031 3. 南昌大学 抚州医学分院,江西抚州,344000 |
| 摘 要： | 以5-羟基-2-戊酮为原料经过酯化、氯化及关环反应,得到中间体2-氨基-4-甲基-5-(2-乙酰氧基)噻唑,在浓H2SO4作用下,用NaNO2和NaH2PO2还原氨基,最后通过皂化反应得到目标产物4-甲基-5-(2-羟乙基)噻唑,采用IR,1H NMR和13C NMR对产物的结构进行了表征确认。 |
| 关 键 词： | 合成 4-甲基-5-(2-羟乙基)噻唑 关环 |
New method for synthesis of 4-methyl-5-thiazoleethanol |
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| ZHANG Xiao-lin,LI Hai-feng,OUYANG Hong-xia,ZHU Li-liang. New method for synthesis of 4-methyl-5-thiazoleethanol[J]. Journal of Nanchang University(Natural Science), 2011, 35(3) | |
| Authors: | ZHANG Xiao-lin LI Hai-feng OUYANG Hong-xia ZHU Li-liang |
| Affiliation: | ZHANG Xiao-lina,b,LI Hai-fenga,OUYANG Hong-xiab,ZHU Li-lianga(a.Department of Chemistry,Nanchang University,Nanchang 330031,China,b.Fuzhou Medical College,Fuzhou 344000,China) |
| Abstract: | 2-amino-4-methyl-5-thiazolylethyl acetate,an reaction intermediate was synthesized from 3-acetyl-propanol via esterification,chloronation and cyclization.Then this chemical was reduced by sodium nitrite and sodium hypophosphite in the presence of concentrated sulfuric acid.Afterward,The target product 4-methyl-5-thiazoleethanol was eventually obtained through saponification.The structures of all compounds were confirmed by IR,1H NMR and 13C NMR. |
| Keywords: | synthesis 4-methyl-5-thiazoleethanol cyclizatio.n |
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