Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids with K4Fe(CN)6 under aerobic conditions |
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| Authors: | Zhengjiang Fu Ligao Jiang Zhaojie Li Yongqing Jiang |
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| Institution: | College of Chemistry, Nanchang University, Nanchang, Jiangxi, China |
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| Abstract: | A method for facile synthesis of aryl nitriles has been well established via Ag/Cu-mediated decarboxylative cyanation of benzoic acids with K4Fe(CN)6 under aerobic conditions. The approach of using readily accessible aryl carboxylic acids and green K4Fe(CN)6 as starting material provides a feasible alternative to previous cyanation protocols. Control experiments revealed the key role of Cu for the process and excluded the possibility of a radical mechanism for the transformation. |
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| Keywords: | Aerobic conditions aryl carboxylic acids aryl nitriles Ag/Cu bimetallic system decarboxylation |
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