A facile and efficient approach for the synthesis of 3-arylthiazol-2(3H)-one |
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| Authors: | Yue Zhu Qilin Wang Haofan Luo Zijuan Wang |
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| Institution: | 1. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China;2. School of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, P. R. China |
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| Abstract: | A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80?°C at first and then in acidic condition at room temperature, to afford products in good yields for a wide range of substrates and a possible mechanism has also been proposed. |
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| Keywords: | Acyl azide 3-arylthiazol-2(3H)-one 1 4-dithiane-2 5-diol facile synthesis nucleophilic addition |
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