Determination of Sulfite in Botanical Medicine Using Headspace Thin-Film Microextraction and Surface Enhanced Raman Spectrometry |
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Authors: | Jing Dong Lemei Cai Shuya Wang |
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Affiliation: | 1. Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis &2. Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China |
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Abstract: | A facile method using headspace thin-film microextraction (HS-TFME) coupled with surface enhanced Raman spectrometry (SERS) has been developed for the determination of sulfite in traditional Chinese herbal medicine. The extraction substrate was synthesized by depositing urchin-like ZnO micron particles on glass sheets using chemical liquid phase deposition. Under the optimal conditions, the intensity of the SERS signal at 630–640?cm?1 provided a good linear relationship with the concentration of sulfite from 25 to 400?mg/kg, and the linear correlation coefficient (R) was 0.996 with a detection limit of 6?mg/kg. The method was employed for the determination of sulfite in herbal medicines, and the results were confirmed by a traditional distillation-titration method. Therefore, this developed HS-TFME-SERS method may play an important role in the rapid, simple, and selective determination of sulfite residues in Chinese herbal medicine and become a potentially universal method for this analyte in various solid samples. |
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Keywords: | Headspace thin-film microextraction (HS-TFME) scanning electron microscopy (SEM) surface enhanced Raman spectrometry (SERS) transmission electron microscopy (TEM) X-ray diffraction (XRD) |
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