Synthesis,antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles |
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| Authors: | Pramod S Phatak Rajubai D Bakale Sambhaji T Dhumal Lalita K Dahiwade Prafulla B Choudhari Vagolu Siva Krishna |
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| Institution: | 1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University Sub-Campus,Osmanabad, MS, India;2. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India;3. Department of Pharmaceutical Chemistry, Bharati Vidhyapeeth College of Pharmacy, Kolhapur, MS, India;4. Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad, India |
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| Abstract: | In a search for safer and potent antitubercular agents, here a library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All synthesized compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv (MTB). Among the screened compounds, 5d, 5e, 5h, and 5l showed good antitubercular activity. The compounds 5d and 5l have shown very effective antitubercular activity against Mycobacterium tuberculosis H37Rv (MTB) with MIC 12.5?μg/mL. All the newly synthesized compounds were thoroughly characterized by 1H NMR, 13C NMR, and HRMS spectral data. We further performed exploratory docking studies on the crystal structure of Mycobacterium tuberculosis enoyl reductase to demonstrate the mechanism of antitubercular activity. |
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| Keywords: | Antitubercular activity click chemistry molecular docking study N-phenylacetamide phthalimide 1 2 3-triazole |
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