L-proline catalyzed multicomponent domino reaction in polyethyleneglycol-400 for regioselective synthesis of pyrazolyl-tetrahydroindazolones under microwave irradiation |
| |
| Authors: | Praveen K Bayannavar Saba Kauser J Shaikh S Madan Kumar Mahadev N Kumbar Aravind R Nesaragi |
| |
| Institution: | 1. Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, India;2. DST-PURSE Laboratory, Mangalore University, Mangalagangothri, Karnataka, India |
| |
| Abstract: | A simple and convenient approach for the synthesis of pyrazolyl-tetrahydroindazolones via L-proline catalyzed three component domino reaction of arylhydrazine, dimedone and pyrazole aldehyde in polyethyleneglycol-400 (PEG-400) under microwave irradiation is described. This novel and green protocol proceeds smoothly in good to excellent yields and provides several advantages such as shorter reaction time, metal-free reaction conditions, simple work-up procedures. Also, recycling of the catalyst and solvent was observed without the loss of activity for three (03) runs. |
| |
| Keywords: | Green synthesis L-proline Multicomponent domino reaction PEG-400 Tetrahydroindazolone |
|
|
