Rapid access to novel 2-alkylthiopyrimidine derivatives and attempt of their Tacrine analogs synthesis |
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Authors: | Chamseddine Derabli Gilbert Kirsch Abdelmadjid Debache |
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Institution: | 1. Laboratoire de Synthèse des Molécules d’Intérêts Biologiques, Université des Frères Mentouri-Constantine, Constantine, Algérie;2. SRSMC, Université de Lorraine, Metz, France |
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Abstract: | A variety of novel 2-alkylthiopyrimidines were synthesized through simple condensation of arylidenemalononitriles with different 2-alkylthiouronium halide derivatives catalyzed by anhydrous potassium carbonate (K2CO3). The reactions have been carried out under mild conditions in i-PrOH, and the products were obtained in moderate to good yields with a simple work-up method. Subsequently, some examples of these compounds have been converted into Tacrine analogs by applying the Friedländer reaction. |
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Keywords: | Friedländer reaction pyrimidine-based heterocycles S-substituted thiopyrimidines Tacrine analogs |
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