In-vitro degradation behavior and biological properties of a novel maleated poly (D,L-lactide-co-glycolide) for biomedical applications |
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| Authors: | Yun Yang Wenjuan Liu Yunhui Zhao Tianlong Huang Jiale Cui |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;2. Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. China;3. Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha, P. R. China |
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| Abstract: | Synthesized biodegradable polymers with controlled degradability and good biological safety would be useful in biomedical applications. In this work a novel maleated poly(D,L-lactide-co-glycolide) (MPLGA) was melt copolymerized from maleic anhydride, D,L-lactide and glycolide monomers. The degradation behavior in phosphate-buffered solution (PBS) was investigated and the biological properties were studied by using fibroblastic cells cultured in an extract of MPLGA and by an in-vitro cell cytotoxicity test. The results indicated that the MPLGA was successfully obtained using the melt-copolymerization method. The maleic anhydride groups in the MPLGA led to a faster degradation in PBS than PLGA. Fibroblastic cells showed normal morphologies in MPLGA extracts, and the MPLGA materials showed no cell cytotoxicity. The in-vitro biological properties indicated that the obtained MPLGA had good biocompatibility and would be useful for medical applications. |
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| Keywords: | biological properties degradation behavior maleated poly(D L-lactide-co-glycolide) maleic anhydride |
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