Facile and efficient synthesis of chiral sulfoxide esters: Versatile tool in asymmetric synthesis |
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| Authors: | Reshma Nagpal Shamsher S Bari Renu Thapar |
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| Institution: | 1. Department of Chemistry, DAV College, Chandigarh, India;2. Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, India;3. University Institute of Engineering and Technology, Panjab University, Chandigarh, India |
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| Abstract: | Facile and efficient synthesis of sulfoxide esters using menthols as chiral auxiliary is described. Phenylthio/benzylthio/naphthylthioacetic esters act as an efficient substrate for chiral sulfoxides via oxidation in one step. The structural and stereochemical aspects of target product were established on the basis of various spectroscopic studies, namely FT-IR, NMR (1H NMR and 13C NMR) and elemental analysis. This method is simple, fast, convenient and very efficient. |
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| Keywords: | β-Lactams chiral sulfoxide ester menthol oxidation |
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