Design and synthesis of cage-like NADH model molecule intermediate with multi-chiral centers |
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| Authors: | Tong Zhang Cui-Bing Bai Yue-Hua Wu Bao-Cai Xu Zhan Yan |
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| Affiliation: | 1. Technical Institute of Physics and Chemistry &2. University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China;3. School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China |
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| Abstract: | Studying NADH molecules is one of the most active areas in biomimetic research. It is important to design novel and efficient chiral NADH model molecules. Herein, a cage-like NADH model with multi-chiral centers was designed, and key intermediates have been synthesized. In this study, we found that pentafluorophenoxy group is an excellent leaving group for our synthetic route. |
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| Keywords: | Cage-like multi-chiral centers NADH symmetry intermediate |
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