Synthesis of imidazobenzothiazine and primidobenazothiazine derivatives via the classic Ullmann cross-coupling reaction of 1,8-diiodonaphthalene with 1H-benzo[d]imidazole-2-thiols or 2-thiouracils |
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| Authors: | Jichun Cui Tongxin Zhang Jianhua Wang Dezhi Liu Jiaqian Wang Jie Liu |
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| Institution: | School of Chemistry and Chemical Engineering, School of Pharmacy, Liaocheng University, Liaocheng, China |
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| Abstract: | A feasible protocol for the synthesis of imidazobenzothiazine and primidobenazothiazine derivatives via the classic copper(I)-catalyzed Ullmann cross-coupling process has been developed. 1,8-Diiodonaphthalene could couple with 2-mercaptobenzimidazoles or 2-thiouracils to give the corresponding benzo4,5]imidazo2,1-b]naphtho1,8-de]1,3]thiazines and 11H-naphtho1,8-de]pyrimido2,1-b]1,3]thiazin-11-ones in moderate yields. |
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| Keywords: | Copper-catalyzed Ullmann cross-coupling imidazobenzothiazines primidobenazothiazines |
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