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Solution dynamics of the natural bioactive molecule capsaicin: a relaxation study |
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| Authors: | Claudia Bonechi Alessio Pardini Gemma Leone Marco Consumi |
| Institution: | 1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy;2. Centre for Colloid and Surface Science (CSGI), University of Florence, Firenze, Italy;3. National Interuniversity Consortium of Materials Science and Technology (INSTM), Firenze, Italy |
| Abstract: | Nuclear magnetic resonance spectroscopy is a straightforward technique for studying molecular dynamics that range in timescale from picosecond (motions faster than molecular reorientation) to those that occur in real-time. This approach is important to highlight the behavior of bioactive molecules in solution, and to acquire information about action mechanisms and potential pharmacological effects. Proton and carbon-13 spin–lattice relaxation experiments were performed to calculate the reorientational correlation time for protonated carbons. Capsaicin showed complex dynamical properties and the results revealed two regions with different dynamical properties: the aliphatic region with fast reorientation motions and the aromatic region with slow motions. |
| Keywords: | Carbon nuclear magnetic resonance relaxation capsaicin dynamical properties proton nuclear magnetic resonance relaxation |