Synthesis,identification and antimicrobial activity of substituted thiazolines and 1,3,4-thiadiazines from dehydroacetic acid |
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| Authors: | Rosa Nechak Yamina Benmalek Naouel Boufroua Bellara Nedjar Kolli Sophie Poulain Martini |
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| Institution: | 1. Laboratory of Applied Organic Chemistry, University of Sciences and Technology Houari Boumediene, Algiers, Algeria;2. Laboratory of microbiology, University of Sciences and Technology Houari Boumediene, Algiers, Algeria;3. Faculty of Sciences of Nice-Sophia Antipolis, CNRS, Nice, France |
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| Abstract: | The reaction of thiosemicarbazones with various α-chloroketones in the presence of anhydrous NaOAc led to 4-thiazolines 5, 7 or 1,3,4-thiadiazines 11 in good yields. Structure elucidation was carried out by 1H, 13C, and FT-IR spectroscopy. The purity of these new products was confirmed by HRMS. A possible mechanism for the formation of 5, 7, and 11 was discussed. All the synthesized novel 4-thiazoline and 1,3,4-thiadiazine derivatives were evaluated in vitro for their antibacterial and antifungal activities against six pathogenic bacteria and a strain of yeast: Escherichia coli ATCC 25992, Pseudomonas aeruginosa ATCC 27852, Staphylococcus aureus ATCC 25923 methicillin-resistant, Staphylococcus aureus ATCC 43300 methicillin-sensitive, Micrococcus luteus ATCC 4698 Enterococcus faecalis ATCC 29212 and Candida albicans IPA (200). Some compounds exhibited relatively significant antibacterial and antifungal activities. |
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| Keywords: | Antimicrobial activity 1 3 4-thiadiazines 4-thiazoline thiosemicarbazones |
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