Determination of phenolic antioxidants in pharmaceutical formulations by liquid chromatography and migration study on HDPE packagings |
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Authors: | N Yagoubi A Baillet C Mur D Baylocq-Ferrier |
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Institution: | (1) Laboratoire de Chimie Analytique, Centre d'Etudes Pharmaceutiques, Rue J. B. Ciément, 92290 Châtenay-Malabry, France |
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Abstract: | Summary The performance of UV diode-array, spectrometric and electrochemical detectors was compared in the chromatographic analysis of trace amounts of six phenolic antioxidants. Quantitative validation was undertaken; the linearity range was wider using UV detection although the limits of detection were lower with electrochemical detection. UV detection was applied both to identification of an antioxidant in a hydrophilic suspension and to a migration study. |
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Keywords: | Column liquid chromatography UV and electrochemical detectors Phenolic antioxidants Migration studies |
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