An efficient stereoselective synthesis of (+)-deoxoprosophylline |
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Authors: | In Su Kim |
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Institution: | College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea |
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Abstract: | An efficient stereoselective synthesis of (+)-deoxoprosophylline from readily available p-anisaldehyde is described. Key steps in the synthesis include the stereoselective amination of anti-1,2-dibenzyl ether using chlorosulfonyl isocyanate, intermolecular olefination, and Pd-catalyzed intramolecular cyclization. |
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Keywords: | Deoxoprosophylline Intermolecular olefination Intramolecular cyclization Chlorosulfonyl isocyanate |
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