LiBF4-Catalyzed three-component coupling of an aldehyde, acetic anhydride and allyltrimethylsilane/TMSCN |
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| Authors: | J.S. Yadav B.V. Subba Reddy P. Vishnumurthy Ch. Janardhana Chary |
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| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | Lithium tetrafluoroborate is found to be an efficient catalyst for allylation and cyanation of aldehydes with allyltrimethylsilane and trimethylsilyl cyanide in the presence of acetic anhydride at room temperature to produce homoallylic acetates and α-cyano acetates in excellent yields. A solution of 10 mol % of LiBF4 in acetonitrile provides a convenient reaction medium to carry out allylation and cyanation reactions under very mild and neutral conditions. |
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| Keywords: | Aldehydes Lithium tetrafluoroborate Allylic acetates α-Cyano acetates |
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