A practical fluorous benzylidene acetal protecting group for a quick synthesis of disaccharides |
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| Authors: | Masaru Kojima |
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| Institution: | Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan |
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| Abstract: | A new fluorous benzylidene acetal protecting group was regioselectively introduced into carbohydrates, deprotected under acidic conditions, and reused. Oligosaccharides were synthesized via regioselective conversion of the fluorous acetal group to the benzyl group by traditional reaction conditions. The fluorous compounds were easily separated from non-fluorous by-products by fluorous solid phase extraction. |
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| Keywords: | Benzylidene acetal group Regioselective reduction Oligosacchrides Fluorous solid phase extraction |
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