Two new biscembranes with unprecedented carbon skeleton and their probable biogenetic precursor from the Hainan soft coral Sarcophyton latum |
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Authors: | Xiao-Hong Yan Guido Cimino |
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Institution: | a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China b Istituto di Chimica Biomolecolare-CNR, 80078, Pozzuoli (Naples), Italy |
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Abstract: | A new cembranolide diterpene, isosarcophytonolide D (1), and two biscembranes with an unprecedented fused carbon skeleton, bislatumlides A (3) and B (4), were isolated from the Hainan soft coral Sarcophyton latum. Their structures and relative stereochemistry were established by 1D and 2D NMR spectroscopic techniques. Compounds 3 and 4 should be obtained by Diels-Alder addition of two cembranoid units. Compound 1 could be one of the biosynthetic precursors. Both 3 and 4 showed mild cytotoxicity toward A549, HT-29, and P388 cell lines. |
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Keywords: | Soft coral Sarcophyton latum Biscembranes |
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