A short synthesis of koniamborine, a naturally occurring pyrano[3,2-b]indole |
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| Authors: | Ronald W. Clawson Jr. |
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| Affiliation: | C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506-6045, USA |
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| Abstract: | An expedient synthesis of the alkaloid koniamborine, the only to date isolated naturally occurring pyrano[3,2-b]indole is presented. The key pyrano[3,2-b]indole forming step is a palladium-catalyzed reductive N-heteroannulation of 2-(4-methoxy-2-nitrophenyl)-(4H)-pyrane-4-one. |
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| Keywords: | Annulation Palladium-catalyzed Alkaloid |
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