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Sc(OTf)3-catalyzed alkylation of indoles with propargyl alcohols: an expeditious synthesis of 3-substituted indoles |
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| Authors: | JS Yadav BV Subba Reddy KV Raghavendra Rao GGKS Narayana Kumar |
| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500 007, India |
| Abstract: | Indoles undergo smooth alkylation with propargylic alcohols in the presence of 10 mol % of scandium triflate under mild conditions to produce 3-propargylated indoles in excellent yields with high selectivity. |
| Keywords: | Scandium(III) triflate Propargyl alcohols Indoles Alkylation |
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