Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-α,α-disubstituted amino acids |
| |
| Authors: | Julia Cianci |
| |
| Institution: | The Walter and Eliza Hall Institute, 4 Research Avenue, Bundoora VIC 3086, Australia |
| |
| Abstract: | Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
