Enantioselective Mannich-type reaction of sulfonylimines having 2-pyridylsulfonyl group as a novel stereocontroller |
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| Authors: | Shuichi Nakamura |
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| Institution: | Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan |
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| Abstract: | A catalytic enantioselective Mannich-type reaction of N-(2-pyridylsulfonyl)imines in the presence of chiral bis(oxazoline)s afforded the products with high enantioselectivity. Asymmetric induction was supposed to be efficiently controlled by a new chiral center on the sulfur dynamically induced through the discriminative coordination of a chiral Lewis acid to one of the sulfonyl oxygens. |
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