Microwave-induced one-pot synthesis of 4-[3-(aryl)-1,2,4-oxadiazol-5-yl]-butan-2-ones under solvent free conditions |
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| Authors: | Jucleiton José R de Freitas Ladjane P da Silva Gisele YV Kimura |
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| Institution: | a Departamento de Química Fundamental, Universidade Federal de Pernambuco, 50.740-540 Recife, PE, Brazil
b Unidade Acadêmica de Garanhuns, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil |
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| Abstract: | The synthesis of 4-3-(aryl)-1,2,4-oxadiazol-5-yl]-butan-2-ones (5a-l) from methyl levulinate (4) and arylamidoximes (1a-l) is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in yields comparable with conventional heating. |
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