Synthesis and self-assembly properties of a novel [poly(ethylene glycol)]-fluorocarbon-phospholipid triblock copolymer |
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| Authors: | Jennifer N Slaughter Julee L Byram |
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| Institution: | a Department of Chemistry, University of Wisconsin, Madison, WI 53705, United States
b School of Pharmacy, University of Wisconsin, Madison, WI 53705, United States |
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| Abstract: | The synthesis of a novel poly(ethylene glycol)-fluorocarbon-phospholipid conjugate that self-assembles into hyper-stable micelles characterized by an internal fluorous phase is described. Physical characterization of the micelles formed by this polymer in aqueous solution is included. Dynamic light scattering (DLS) measurements indicate a mean diameter of 15 nm (±3 nm), while pyrene fluorescence studies show a critical micelle concentration (CMC) of only 0.65 μM. |
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