Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts |
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Authors: | Chia-Wei Yang |
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Affiliation: | Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC |
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Abstract: | CpRu(PPh3)2Cl and DBU dual catalysts in combination enable a one-pot annulation of 1-R-3-en-1-yn-5-als (R = aryl, alkenyl, alkyl) and cycloalkanones to give highly substituted benzene products. This catalytic reaction consists of a tandem aldol condensation, dehydration and aromatization through a 1,7-hydrogen shift; the resulting 1-indanones and α-tetralones are obtained in moderate to good yields. |
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