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An improved synthesis of Fmoc-N-methyl serine and threonine |
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| Authors: | Rajesh H Bahekar Pradip A Jadav Dipam N Patel Vijay M Prajapati Arun A Gupta Mukul R Jain Pankaj R Patel |
| Institution: | Zydus Research Center, Cadila Healthcare Ltd., Sarkhej-Bavala N.H. 8A, Moraiya, Ahmedabad 382 210, India |
| Abstract: | An improved method for the synthesis of Fmoc-N-methyl serine and threonine has been developed, which involves formation and subsequent reduction of the corresponding oxazolidinone with a Lewis acid under mild conditions, with improved yields and shorter reaction times. |
| Keywords: | Fmoc-N-methyl serine Fmoc-N-methyl threonine Oxazolidinones Lewis acid β-hydroxy amino acids |
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