Total synthesis of aculeatins A and B via a tethered oxa-Michael approach |
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| Authors: | S. Chandrasekhar Ch. Rambabu T. Shyamsunder |
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| Affiliation: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A stereocontrolled total synthesis of aculeatins A and B has been achieved in eight steps and in 15% overall yield. The key feature of this synthetic approach is the application of a Marouka allylation and tethered intramolecular oxa-Michael reaction to install the required stereocentres on the tetrahydropyran ring. |
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| Keywords: | Aculeatin Marouka allylation Oxa-Michael reaction Spirocyclic natural products |
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