An efficient synthesis of 4-bromo-N-substituted oxindoles by an intramolecular copper-catalyzed amidation reaction |
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| Authors: | Adri van den Hoogenband Jos H.M. Lange Jack A.J. den Hartog Remco Henzen Jan Willem Terpstra |
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| Affiliation: | Solvay Pharmaceuticals, Research Laboratories, C. J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands |
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| Abstract: | A highly efficient synthetic approach to novel 4-bromo-N-substituted oxindoles is described. The method involves a mild intramolecular copper-catalyzed amidation reaction of N-substituted 2,6-dibromophenylacetamides. In contrast to our recently published palladium-catalyzed amidation reaction, no concomitant dimerization on the 3-position of the formed oxindole occurs. |
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