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Anhydrocochlioquinone A, a new antitumor compound from Bipolaris oryzae |
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| Authors: | Preecha Phuwapraisirisan Knokwan Sawang Pongpun Siripong |
| Affiliation: | a Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand b Program of Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand c Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand |
| Abstract: | In the search for antitumor compounds from Bipolaris oryzae, the coexistence of ophiobolins and cochlioquinones is reported for the first time. Of the compounds isolated, anhydrocochlioquinone A (7) was identified as a new antitumor agent. The structure of 7 was fully characterized by spectroscopic data, including COSY, HSQC, HMBC, and NOESY. The cytotoxicity of isolated compounds against HeLa and KB cells is also described. |
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