Synthesis of aza analogues of the anticancer agent batracylin |
| |
| Authors: | Carlos M. Martí nez-Viturro |
| |
| Affiliation: | Departamento de Química Orgánica y Unidad Asociada al CSIC, Facultad de Química, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain |
| |
| Abstract: | Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin. |
| |
| Keywords: | Batracylin Quinazolines Pyridines Mitsunobu reaction Quinazolinones |
| 本文献已被 ScienceDirect 等数据库收录！ |
