A novel, one-pot, three-component synthesis of 4H-pyrido[1,2-a]pyrimidines |
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| Authors: | Mehdi Adib Mohammad Hosein Sayahi Long-Guan Zhu |
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| Institution: | a School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
b Chemistry Department, Zhejiang University, Hangzhou 310027, PR China |
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| Abstract: | A novel, one-pot, three-component synthesis of 4H-pyrido1,2-a]pyrimidines is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedicarboxylates, was trapped by N-(2-pyridyl)amides to produce the title compounds under mild reaction conditions in good yields. |
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| Keywords: | N-(2-Pyridyl)amides Acetylenic esters Isocyanides 4H-Pyrido[1 2-a]pyrimidines Three-component synthesis |
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