Multicomponent synthesis of imidazo[1,2-a]pyridines using catalytic zinc chloride |
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Authors: | Amanda L Rousseau Pulane Matlaba Christopher J Parkinson |
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Institution: | Discovery Chemistry, Biosciences, CSIR, Private Bag X2, Modderfontein 1645, South Africa |
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Abstract: | The novel use of zinc chloride to catalyze the one-pot, three component synthesis of imidazo1,2-a]pyridines from a range of substrates using either conventional heating or microwave irradiation is described. This methodology affords a number of imidazo1,2-a]pyridines in reasonable yields and short reaction times without any significant optimization of the reaction conditions. |
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Keywords: | Multicomponent reaction Imidazo[1 2-a]pyridines Zinc chloride Montmorillonite K10 |
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