TaBr5-catalyzed Biginelli reaction: one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions |
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| Authors: | Naseem Ahmed |
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| Affiliation: | Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4 |
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| Abstract: | An efficient TaBr5 (5-10 mol %)-catalyzed Biginelli reaction under solvent-free conditions for one-pot syntheses of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) and their thione analogs is reported. The catalyst is stable at room temperature and employed under mild and environmentally friendly conditions. |
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| Keywords: | TaBr5-catalyzed Biginelli reaction Solvent-free conditions 3,4-Dihydropyrimidin-2-(1H)-ones/thiones |
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