Synthesis of poly-substituted pyrroles starting from the Baylis-Hillman adducts |
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Authors: | Hyun Seung Lee |
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Institution: | Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju 500-757, Republic of Korea |
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Abstract: | We synthesized poly-substituted pyrrole derivatives 4a-e, 7a-c and 10a-d from the reaction of phenacyl bromide and the aza-Baylis-Hillman adducts 1a-d or their rearranged derivatives 5a-e. The pyrroles were synthesized via the successive N-alkylation, Michael addition, elimination of p-toluenesulfinic acid and oxidative aromatization processes. |
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Keywords: | Poly-substituted pyrroles Baylis-Hillman adducts Michael addition DBU |
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