Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno[2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine |
| |
| Authors: | Sté phanie Hesse,Enrico Perspicace,Gilbert Kirsch |
| |
| Affiliation: | Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, Université Paul Verlaine—Metz, 1 Boulevard Arago, 57070 METZ Technopôle, France |
| |
| Abstract: | A two-minute microwave irradiation allowed the synthesis of several 2-aminothiophene-3-carboxylic acid derivatives. Their efficient transformation to thieno[2,3-d]pyrimidin-4-one and the corresponding 4-chloro derivative is also reported under microwave irradiation. |
| |
| Keywords: | Gewald synthesis 2-Aminothiophenes Thienopyrimidinones Microwave-assisted synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
