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A selective turn-on fluorescent sensor for Fe and application to bioimaging |
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| Authors: | Meng Zhang Manyu Li Mengxiao Yu Lei Li Jianping Zhang Tao Yi |
| Institution: | a Department of Chemistry and Advanced Materials Laboratory, Fudan University, Shanghai 200433, PR China b Hospital of Xinhua, Medicine School of Shanghai Jiaotong University, Shanghai 200092, PR China c State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 1000872, PR China d Department of Chemistry, Renmin University of China, Beijing 1000872, PR China e Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200433, PR China |
| Abstract: | A novel compound FD1 was demonstrated as a turn-on fluorescent sensor for imaging of iron(III) ion in biological samples. Based on the spirolactam (nonfluorescence) to ring-open amide (fluorescence) equilibrium, FD1 exhibited high selectivity and sensitivity for Fe3+ over other metal ions. Moreover, fluorescent microscopy experiments further established that FD1 could be used for sensing Fe3+ within living cells. |
| Keywords: | Fluorescent sensor Bioimaging Fe3+ |
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