Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera |
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| Authors: | Wei-Lie Xiao Li-Mei Li Sheng-Xiong Huang Chun Lei Rui-Rui Wang Rong-Tao Li |
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| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 Yunnan, PR China
b Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, PR China |
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| Abstract: | Four novel highly oxygenated trinortriterpenoids, sphenalactones A-D (1-4), were isolated from the leaves and stems of Schisandra sphenanthera and their structures were elucidated by extensive analysis of 1D and 2D NMR data. Compounds 1-4 featured a C27 backbone and showed anti-HIV-1 activity with EC50 values in the range of 35.5-89.1 μg/mL with low cytotoxicity against C8166 cells (CC50 > 200 μg/mL). |
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| Keywords: | Schisandra sphenanthera Sphenalactones A-D Trinortriterpenoid Anti-HIV activity |
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