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Synthesis of a fluoroalkene peptidomimetic precursor of N-acetyl-l-glutamyl-l-alanine |
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| Authors: | Carole Lamy Hélène Parrot-Lopez |
| Institution: | a ICBMS, CNRS, UMR 5246, Laboratoire Chimie Organique 2—Glycochimie, Université de Lyon, Université Lyon 1, Bât. 308—CPE Lyon, 43, Bd du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France b Innsbruck Medical University, Biocenter, Division of Medical Biochemistry, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria |
| Abstract: | Fluoroolefin peptidomimetics of the dipeptide N-acetyl-Glu-Ala were synthesized via an Evans asymmetric aldol reaction and an Overman rearrangement. This dipeptide is the N-terminal of an octapeptide implicated in the signal transduction via PKCε. |
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