Direct synthesis of protected diethyl 1,2-diaminoalkylphosphonates |
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| Authors: | Roman B?aszczyk |
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| Affiliation: | Institute of Organic Chemistry, Technical University of Lodz (Politechnika), ?eromskiego St. 116, 90-924 Lodz, Poland |
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| Abstract: | An efficient, diastereoselective synthesis of 5-substituted (2-thioxo-imidazolidin-4-yl)phosphonic acid diethyl esters from metallated diethyl isothiocyanatomethylphosphonate and activated imines has been developed. The three-step transformation of imidazolidine-2-thione derivatives into 1,2-diaminoalkylphosphonic acids is also described. |
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| Keywords: | Nucleophilic addition Imines Imidazolidine-2-thiones 1,2-diaminoalkylphosphonic acids Diethyl isothiocyanatomethylphosphonate Isothiocyanates |
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