A new approach to the 1,10-phenanthroline core |
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Authors: | Giorgio Chelucci Daniele Addis Salvatore Baldino |
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Institution: | Dipartimento di Chimica, Università di Sassari, via Vienna 2, I-07100 Sassari, Italy |
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Abstract: | A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of cis-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinaldehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. |
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Keywords: | 1 10-Phenanthroline Nitrogen heterocycles Intramolecular coupling Ullmann reaction |
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