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Deacetalisation-bicyclisation routes to novel polycyclic heterocycles using stannous chloride dihydrate
Authors:Alex N. Cayley,Cé  cilia Mé  nard-Moyon,Richard J.K. Taylor
Affiliation:a University of York, Department of Chemistry, Heslington, York YO10 5DD, UK
b AstraZeneca R&D Charnwood, Medicinal Chemistry, Bakewell Road, Loughborough LE11 5RH, UK
Abstract:The stannous chloride dihydrate-mediated deprotection-bicyclisation of a range of amides possessing a pendant acetal group is reported. These mild reaction conditions have been used to prepare a number of ring-fused heterocyclic compounds, some in enantiomerically pure form, which should be of interest both in their own right and as building blocks for the production of more complex target molecules.
Keywords:Heterocycles   Stannous chloride   Deacetalisation   Bicyclisation
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