The Cu-catalyzed exo-selective asymmetric multicomponent [C+NC+CC] coupling reaction |
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Authors: | Philip Garner Jieyu Hu Wiley J Youngs |
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Institution: | a Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106-7078, United States b Department of Chemistry, University of Akron, Akron, OH 44325, United States |
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Abstract: | A novel CuI-catalyzed exo-selective asymmetric C+NC+CC] coupling reaction is reported that provides unprecedented access to a variety of highly functionalized 4,5-trans disubstituted pyrrolidines in a single operation. The reaction complements and extends our AgI-catalyzed endo-selective C+NC+CC] asymmetric coupling reaction. |
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