An improved synthesis of 2-(1,2,4-thiadiazol-5-yl)pyridine by interception of an intermediate involved in a competing cyclisation reaction |
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Authors: | Chris Richardson |
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Affiliation: | Department of Chemistry, University of Canterbury, Christchurch, New Zealand |
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Abstract: | Reaction of thiopicolinamide with N,N′-dimethylformamide dimethyl acetal leads to the formation of 3-(dimethylamino)-1-methylthioimidazo[1,5-a]pyridine (3). However, the course of the reaction can be diverted to produce the title compound (1) in good yield by timely interception of the intermediate thioacylamidine (2). |
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Keywords: | N-Ligand 1,2,4-Thiadiazole Imidazo[1,5-a]pyridine |
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